Brand

Thanks to explosive arrows, Brand is a viable choice for fire auradins and enchantresses. However, it lacks pierce, so Kuko Shakaku or Demon Machine may be a better choice.
Also, if our build is purely elemental, and we use Lower Resist on a switch, Brand's Amplify Damage proc will override it.

Main disadvantage of this costly and otherwise powerful runeword is the lack of inherent speed. Compared to massive stopping power of an Ice, or speed of Faith, Brand remains unpopular choice.