Wrath

Although some argue that this runeword is not worth to make because of

Ber, I think it's really effective against Physical Immunes (because of added elemental and magic damage) and bosses (because of crushing blow). I use Faith as a primary weapon and Wrath on swap and it's enough for a bowazon to handle pretty much anything in the game. Without Wrath I had issues with monsters like Hell Temptress or Spectre (

Atma's Scarab

Amplify Damage proc wasn't enough when handling large packs of those). Wrath can also be seen as a more DPS version of Harmony runeword.

Because of curse proc and Crushing Blow I think the best base is

Matriarchal Bow (because of better IAS breakpoints).