Grief

A slvl 15

Venom: Skill proc has the following effects:
Poison Damage Min: 305
Poison Damage Max: 325
Poison Duration (seconds): 0.4
Duration (seconds): 176

A

Phase Blade Grief, whose massive Damage +X attribute will rapidly outstrip all but the highest Enhanced Damage +X% weapon modifiers, is undisputedly BiS for most weapon-related builds. It is more succinct to list the builds for which Grief is not BiS:

Blade Fury Assassins, who enjoy a sizable Damage +X bonus from the skill itself, are better served by weapons offering off-weapon damage bonuses, such as Beast's

Fanaticism aura or Last Wish's Might aura.

Vengeance Paladins would prefer nearly any other weapon, as Damage +X is added after the bonus elemental damage of the

Vengeance skill.

Fire Claws Druids use their weapon as a vector for the skill's sizable flat fire damage. meaning other options - such as Phoenix or Hustle - may offer more than Grief's admittedly high increased IAS and Ignore Target Defense.

Auradin builds using Dragon or Doom will necessarily prefer those weapons.

A Dream Sorceresses or Enchantresses will generally prefer faster or more flexible vectors for their damage, such as

Griswold's Redemption, Passion, or

Warshrike.

Melee characters for whom attack speed is inconsequential, such as

Charge Paladins or

Leap Attack Barbarians, will typically prefer an etherial Death, as its damage output will exceed Grief's.