The simple, disappointing, boring answer is... time. I started playing online 2 years ago, but before I hit 1 year I already had enough runes to do whatever I wanted: multiple Enigma, Faith, Breath of the Dying, etc.
I don't even trade THAT much, plus don't trade for items (just consumables: gems, keys, runes). And I play super casual and definitely don't optimize my tasks, I just do whatever I feel like doing at any time.
Just keep playing and you'll naturally get there. Sell everything you don't use.
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IamSteve
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