Pindleskin

After testing, It is now confirmed that the portal to

Nihlathak's Temple does NOT close if you get the waypoint and kill

Nihlathak. The portal now remains open all the time.

Pindleskin is a Super Unique which means he always drops 2 items of Magic quality with chances for upgrades to Rare, Set, Unique, etc (unless he drop a rune/gem).
This chance for upgrade is directly affected by you Magic Finding %.

Since the number of drops are fixed for Super Uniques it is usually more beneficial to farm him on lower player counts (commonly P1). Typically you'll want to increase your MF as much as you can and make your 'Pindle Runs' as fast as possible. Only increase the player count if you can clear him and his minions equally fast. While increasing the player count won't affect

Pindleskin drop rates it will increase the XP gained per run and the drop chances for his minions.

In D2R, Blizzard removed the old "Realm Down" feature of D2LOD and replaced it with a game join timer. Previously, you had to wait out a 30-minute timeout if you quit and joined too many online games too quickly within a set span of time, which added a layer of tediousness to Pindle farming: you had to find a way to meaningfully extend your game sessions to avoid this timeout; the most popular method was adding Eldritch and Shenk to your runs. In D2R, you don't need to do that. The new game join timer starts at the minimum of 10 seconds (a single Pindle kill always takes longer) when the servers aren't experiencing a heavy load and goes up the more people are currently online (90 seconds max).

The Pindle Run - Vorpal4's

Pindleskin project.

Pindle and his pack can be very dangerous if spawned with Might Aura, Extra Strong, Cursed, or any combination of the above on Player 7-8 settings. The cramped area in which he spawns also can be hazardous for nonteleporting characters (particularly Hammerdins or FoH paladins without Enigma) In such circumstances you can get 1 or 2 shotted with 2K life.

Player 3 settings is the ideal way to farm Pindle efficiently if you're spamming terrorized Pindle runs, particularly if youre HC where survival is priority. P7-P8 generally does not affect drops enough to justify the extra risk and the extra XP gain is generally not worth the extra risk either unless you can consistently and reliably obliterate Pindle and his entire pack quicker than they can bumrush you.