You can have several of these jewels in your inventory, but you can only equip one item with such a jewel at a time. This makes the colossal ancient jewels similar to Gheed's Fortune, the Hellfire Torch or the Annihilus.
Protector's Stone is affected by the %ed + min/max damage bug if socketed in an armor piece (more info). Until this bug is fixed, you should try to insert it into your weapon whenever possible.
If you play an Assassin and want to use Burst of Speed or Fade, you shouldn't use Protector's Stone.
Whenever the chance to cast Fade from Protector's Stone is triggered, it will overwrite your previous instance of Burst of Speed or Fade (even if you previously had a higher level of Fade).
While this is easy to spot with Burst of Speed, it can remain unnoticed with Fade and lead to a quick death if your build depends on a high level of Fade for survivability.
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