Runes for the Rune Master

A little advice or help needed here. So I have a 5os

Rune Master, deciding what to put in. I have a few 30+ %ED jewels with 15 IAS, so was thinking to add 2x of those to get 60+ ED and 30 IAS. But was curious to add maybe runes for these affixes

Um - +25% Open wounds

Mal - Prevent Monster Heal

Lo - +20% Deadly strike

Ber - +20% Crushing blow

From my Memory (which is poor) I always thought Open Wounds was good with poison damage (boy oh boy could I ever be wrong on that one). One way this weapon will be use is for

Smite and not

Zeal, so yes maybe I could add more

Shael so I look like a coked up meth head on crack. Thinking more a weapon that can aid both

Zeal &

Smite.

I should add, I have a really good eDeath & Doom, & Grief. The

Rune Master is a "End of ladder, I am bored, lets do stupid stuff". I have a 33% ED & 29 Light resist jewel that made me think to try something whacky with Uber Meph. I am inclined towards adding

Um &

Ber. Would love to hear others thoughts